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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF4E
All Species:
0
Human Site:
S124
Identified Species:
0
UniProt:
P06730
Number Species:
16
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P06730
NP_001959.1
217
25097
S124
L
N
K
Q
Q
R
R
S
D
L
D
R
F
W
L
Chimpanzee
Pan troglodytes
XP_523824
217
24938
Rhesus Macaque
Macaca mulatta
XP_001092045
253
28850
Dog
Lupus familis
XP_544992
217
25075
Cat
Felis silvestris
Mouse
Mus musculus
Q3UTA9
244
27967
Rat
Rattus norvegicus
P63074
217
25035
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514651
236
27161
Chicken
Gallus gallus
XP_420655
217
25026
Frog
Xenopus laevis
P48597
213
24616
Zebra Danio
Brachydanio rerio
Q9DFS6
215
24831
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P48598
259
29205
Honey Bee
Apis mellifera
XP_624290
213
24784
Nematode Worm
Caenorhab. elegans
O61955
248
27791
Sea Urchin
Strong. purpuratus
NP_001091928
225
25645
Poplar Tree
Populus trichocarpa
Maize
Zea mays
O81481
218
24452
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O23252
235
26501
Baker's Yeast
Sacchar. cerevisiae
P07260
213
24236
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.6
59.2
99.5
N.A.
53.2
98.1
N.A.
71.6
92.1
88.4
82.9
N.A.
43.6
54.8
41.1
53.7
Protein Similarity:
100
98.6
69.1
99.5
N.A.
69.2
98.6
N.A.
74.1
94
94
92.6
N.A.
56.3
68.6
58.8
73.7
P-Site Identity:
100
0
0
0
N.A.
0
0
N.A.
0
0
0
0
N.A.
0
0
0
0
P-Site Similarity:
100
0
0
0
N.A.
0
0
N.A.
0
0
0
0
N.A.
0
0
0
0
Percent
Protein Identity:
N.A.
42.2
N.A.
39.5
31.8
N.A.
Protein Similarity:
N.A.
56.8
N.A.
54
55.3
N.A.
P-Site Identity:
N.A.
0
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
0
N.A.
0
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
100
0
100
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
100
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
100
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
100
0
0
0
0
0
0
0
0
100
0
0
0
0
100
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
100
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
100
100
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
100
100
0
0
0
0
100
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
100
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
100
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _